ICP-MS

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ICP-MS Method Development & System Proficiency Training

Following our proficient on-site engagement, your staff won't just be certified; They will be advanced operators, fully equipped with the knowledge and confidence that guarantee the continuity of your lab's high-performance operation.

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Module 1: ICP-MS Fundamentals and Instrumentation

Principles of ICP-MS
- Review of atomic structure and the ionization process
- Understanding Mass Spectrometry (MS) principles: mass-to-charge ratio (m/z)
ICP-MS Instrument Components
- Detailed function of the Sample Introduction System
- The Interface and vacuum system
- Ion Optics and their role in ion focusing
- Detector types and performance characteristics.
Basic Operation and Startup
- Proper instrument startup and shutdown procedures
- Software familiarization
- Daily and weekly System Suitability Tests (SST)

Module 2: Advanced Method Development & Interference Management

Sample Preparation & Matrix Effects
- Selecting appropriate digestion methods
- Understanding and mitigating matrix effects
- The role of internal standards and their correct selection
Interference Correction Strategies
- Identifying and correcting Isobaric Interferences
- Utilizing Collision and Reaction Cells
Method Optimization & Tuning
- Optimizing plasma conditions for sensitivity and robustness
- Tuning procedures, establishing optimum analytical parameters for different sample types
Calibration and Quantitation
- Calibration approaches : external calibration, matrix matching, standard addition, isotopic dilution
- Determining Method Detection Limits (MDL) and Limit of Quantitation (LOQ)

Module 3: Validation, Compliance & Data Integrity

Method Frameworks
- Overview of relevant regulations
- Designing a Validation Protocol checklist specific to ICP-MS parameters (Accuracy, Precision, Linearity, etc.)
Data Integrity and Auditing
- Generating audit trails and maintaining records
- Proper data handling, processing, and reporting protocols.
Performance Monitoring & OOS
- Establishing Quality Control (QC) criteria and action limits
- Procedures for Out-of-Specification (OOS) investigations specific to ICP-MS analysis
- Change control implementation for method updates.

Module 4: System Maintenance and Advanced Troubleshooting

Preventative Maintenance
- Scheduled maintenance for the sample introduction system
- Cone maintenance: cleaning and replacing sampler/skimmer cones
Advanced Troubleshooting Logic
- Systematic diagnosis of common issues: low signal, poor precision, high background noise
- Identifying the root cause of issues: sample introduction, plasma, or mass spectrometer component failure.
Minimizing Risk & Operational Success
- Creating clear, optimized, and documented SOPs for every method
- Strategies for reducing dependence on a single individual's knowledge.

Training syllabus

This course delivers expertise in ICP-MS system proficiency and robust method development. You will gain practical skills to ensure guaranteed compliance and data integrity, alongside advanced maintenance and troubleshooting for sustained, high-quality performance.

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