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Single Particle ICP-MS

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Single Particle ICP-MS Method Development & System Proficiency Training

​Following our proficient on-site engagement, your staff won't just be certified; They will be advanced operators, fully equipped with the knowledge and confidence that guarantee the continuity of your lab's high-performance operation.​

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Module 1: SP-ICP-MS Instrumental Optimization

  • Transient Signal Acquisition

    • Master High-Speed Data Acquisition using short dwell times (≤100μs)

    • Understand the impact of quadrupole scan speed and TOF analyzers

  • Sample Introduction for Particles

    • Optimize nebulizer/spray chamber for maximum nebulization efficiency (ηneb​)

    • Optimize plasma parameters for stability and particle desolvation/ionization

  • Counting Efficiency and LOD/LOQ

    • Determine Particle Transport Efficiency (ηtrans​)

    • Calculate Mass (LODmass​) and Particle Size (LODsize​) limits of detection

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Module 2: SP-ICP-MS Method Development and Calibration

  • Particle Size and Mass Calibration

    • Convert ion intensity to particle mass using a dissolved standard curve

    • Calculate particle diameter based on mass and density

    • Use Certified Nanoparticle Reference Materials (RMs) for size verification

  • Particle Number Concentration

    • Calculate Number Concentration (particles/mL) using transport efficiency

    • Correct for Poisson statistics (missed events) at high concentration

  • Matrix Effects and Particle Stability

    • Maintain nanoparticle stability in solution (e.g., pH, ionic strength)

    • Separate the dissolved fraction signal from the particle signal

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Module 3: Advanced Data Processing and Analysis

  • Data Filtering and Processing

    • Differentiate between true particle events and matrix noise

    • Apply Baseline correction and thresholding near the LODsize​

  • Distribution and Statistics

    • Generate and interpret particle size distribution (PSD) histograms

    • Calculate key metrics: mean diameter, mode, standard deviation, and polydispersity index

  • Coincidence Correction

    • Understand the phenomenon of multiple particle events (coincidence) within a single dwell time

    • Apply mathematical correction models to accurately quantify number concentration

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Module 4: SP-ICP-MS Applications and Compliance

  • Applications in Environmental and Food Science

    • Characterize Engineered Nanomaterials (ENMs) in complex matrices (water, soil)

    • Analyze TiO2​ and Ag nanoparticles in food and cosmetics.

  • Hyphenated Techniques

    • Introduce Asymmetrical Flow Field-Flow Fractionation (AF4-SP-ICP-MS) for particle separation - Use AF4 for high-resolution analysis of size and composition

  • Regulatory Guidelines and Method Validation

    • Overview of current FDA/EPA guidelines for nanomaterial characterization

    • Master Validation requirements for SP-ICP-MS methods: accuracy, precision, and robustness for particle size and number concentration

Training syllabus

This course delivers expertise in SP-ICP-MS System Optimization and advanced method development, focusing on transient signal acquisition, particle calibration, and size analysis. You'll gain practical skills in advanced data processing (including coincidence correction) and master regulatory guidelines for sustained, high-quality nanoparticle characterization.

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