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Laser Ablation ICP-MS

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Laser Ablation ICP-MS Method Development & System Proficiency Training

Following our proficient on-site engagement, your staff won't just be certified; They will be advanced operators, fully equipped with the knowledge and confidence that guarantee the continuity of your lab's high-performance operation.​

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Module 1: Fundamentals of Laser Ablation and Aerosol Transport

  • Principles of Laser Ablation

    • Understand photothermal vs. photoionization ablation theory

    • Master the influence of Laser Parameters (Wavelength, Fluence, Pulse Duration)

    • Compare ablation of transparent vs. opaque materials.

  • The LA-ICP-MS Interface

    • Optimize Ablation Cell Design for fast washout and spatial resolution

    • Master Aerosol Transport using carrier gases (He/Ar)

    • Understand Particle Size and elemental fractionation

  • Sample Preparation and Setup

    • Handle solid Sample Requirements (polished sections)

    • Set up the Optical Setup: focusing the laser and determining spot size

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Module 2: Quantitative Analysis and Calibration Strategies

  • Internal Standardization and Correction

    • Use Internal Standards to correct for variable ablation yield and drift

    • Select appropriate Internal Standards (e.g., Si/Ca)

    • Optimize Ablation Protocols and Time-Resolved Analysis (TRA)

  • Calibration and Matrix Effects

    • Meet the critical need for Matrix-Matched Solid Reference Materials

    • Introduce Non-Matrix-Matched Calibration methods

    • Utilize software for Data Processing (normalization, background/drift correction).

  • Quality Control and Validation

    • Use Certified Reference Materials (CRMs) to validate accuracy

    • Report final concentrations with appropriate measurement uncertainty

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Module 3: Advanced Applications and System Maintenance

  • Spatially Resolved Analysis

    • Master Depth Profiling and Elemental Mapping (Imaging LA-ICP-MS)

    • Use LA-ICP-MS for high-precision Isotope Ratio Measurement.

  • Applications

    • Explore applications in geosciences, materials science, and bio-imaging (tissue mapping).

  • System Maintenance

    • Perform routine Laser and Optics cleaning and focusing checks

    • Maintain the Aerosol Path and ICP-MS torch injector

    • Ensure adherence to Class 1 Laser safety protocols

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Module 4: LA-ICP-MS Data Processing and Validation

  • Quantitative Data Processing

    • Use software for Background Subtraction and TRA integration

    • Apply Advanced Drift Correction (piece-wise, non-linear)

    • Master Internal Standard Normalization to correct for ablation yield

  • Method Validation and Quality Control (QC)

    • Define LOD/LOQ for solid materials and transient signals

    • Establish Accuracy and Precision criteria

    • Design a QC Sequence using secondary CRMs and Drift Monitors

    • Report Spatial Resolution as a critical metric.

  • Data Integrity and Reporting

    • Ensure Data Integrity for TRA data and processing software

    • Report final concentrations, including Internal Standard value and measurement uncertainty

    • Create detailed SOPs and manage Out-of-Specification (OOS) results

Training syllabus

This course delivers expertise in LA-ICP-MS System Fundamentals and advanced quantitative analysis, focusing on laser-solid interaction, aerosol transport, and the crucial use of solid standards. You'll gain practical skills in data processing (normalization/drift correction) and master spatial analysis (depth profiling/imaging) for applications in geosciences, materials, and bio-imaging.

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